Research Paper Volume 16, Issue 1 pp 872—910

Figure 14. Analysis of genetic mutation and methylation levels of XRCC1 and hub-gene and pathway regulation in LGG. (A) Homozygous/heterozygous CNV of XRCC1 and its related genes in LGG. Homo Amp: homozygous amplification; Hete Amp: heterozygous amplification; Homo Del: homozygous deletion; Hete Del: heterozygous deletion; None: without CNV. (B) The heterozygous CNV of XRCC1 and (C) the correlation between CNV and mRNA RSEM. The heterozygous CNV of XRCC1 and the correlation between CNV and mRNA RSEM in LGG were plotted to utilize GSCALite. (D) The overall survival discrepancy between hypermethylation and hypomethylation of XRCC1 and its related genes in LGG. (E) In the correlation between methylation and gene expression in LGG, blue represented a negative correlation, while red represented a positive correlation. (F) XRCC1 and hub genes influence pathways that participate in the development, growth, and progression of LGG. (G) The inferred activity of the identified four target genes in pathways that participate in the development, growth, and progression of LGG. A and I to mark the active and inhibited pathways, respectively. (H) The correlation of XRCC1 expression and LGG drug sensitivity.