Research Paper Volume 16, Issue 2 pp 1318—1335
Long non-coding RNA MEG3 acts as a suppressor in breast cancer by regulating miR-330/CNN1
Figure 4. Validation of interaction among lncRNA MEG3, miR-330 and CNN1. (A) Effect of lncRNA MEG3 overexpression on miR-330 expression and CNN1 mRNA expression. Up panel, MCF-7 cells; below panel, BT-474 cells. (B) Effect of lncRNA MEG3 overexpression on CNN1 protein expression. **P < 0.01 vs. blank; ##P < 0.01 vs. lncRNA NC. (C) Luciferase reporter assay. **P < 0.01 vs. psicheck2 + mimic NC. (D) lncRNA MEG3 binds to miR-330 by RIP assay. **P < 0.01 vs. NC mimic.