Exploring the effect and mechanism of Aloin A against cancer cachexia-induced muscle atrophy via network pharmacology, molecular docking, molecular dynamics and experimental validation

Awaguli Dawuti; Lisha Ma; Xueyan An; Jiawei Guan; Changdong Zhou; Linyun He; Yue Xu; Bo Han; Abudumijiti Abulizi

doi:doi:10.18632/aging.205416

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Research Paper Volume 15, Issue 24 pp 15557—15577

Exploring the effect and mechanism of Aloin A against cancer cachexia-induced muscle atrophy via network pharmacology, molecular docking, molecular dynamics and experimental validation

Figure 8. The analysis of Aloin A-target interactions by binding free energies. (A) Binding free energy of HSP90AA1-Aloin A. (B) Binding free energy of AKT-Aloin A. (C) Binding free energy of AKT3-Aloin A.