Exploring the effect and mechanism of Aloin A against cancer cachexia-induced muscle atrophy via network pharmacology, molecular docking, molecular dynamics and experimental validation

Awaguli Dawuti; Lisha Ma; Xueyan An; Jiawei Guan; Changdong Zhou; Linyun He; Yue Xu; Bo Han; Abudumijiti Abulizi

doi:doi:10.18632/aging.205416

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Research Paper Volume 15, Issue 24 pp 15557—15577

Exploring the effect and mechanism of Aloin A against cancer cachexia-induced muscle atrophy via network pharmacology, molecular docking, molecular dynamics and experimental validation

Figure 6. Molecular docking of Aloin A with top targets. (A) Aloin A-HSP90AA1. (B) Aloin A-Akt1. (C) Aloin A-CTNNB1. (D) Aloin A-SRC. (E) Aloin A-AKT3. (F) Aloin A-TNF-α. (G) Aloin A-RELA. (H) Aloin A-BCL2.