Danggui-Shaoyao-San (DSS) ameliorates the progression of osteoarthritis via suppressing the NF-κB signaling pathway: an <i>in vitro</i> and <i>in vivo</i> study combined with bioinformatics analysis

Shuai Chen; Pan Kang; Zhuanglin Zhao; Hongyi Zhang; Jianliang Li; Kun Xu; Dawei Gong; Feng Jiao; Haibin Wang; Meng Zhang

doi:doi:10.18632/aging.205410

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Research Paper Volume 16, Issue 1 pp 648—664

Danggui-Shaoyao-San (DSS) ameliorates the progression of osteoarthritis via suppressing the NF-κB signaling pathway: an in vitro and in vivo study combined with bioinformatics analysis

Figure 8. DSS ameliorated OA progression in a rat OA model in vivo. (A) Representative H&E and Safranin O staining of cartilage and synovitis from different experimental groups. (B) Immunohistochemical staining of MMP13 and P65 was employed to evaluate the effect of DSS on the cartilage. (C) Quantitative analysis of positive cells in cartilage. ^####p < 0.0001 vs. sham group; ^**p < 0.01, ^***p < 0.001, ^****p < 0.0001 vs. OA group, n = 6.