Research Paper Volume 16, Issue 1 pp 627—647
Targeting of FSP1 regulates iron homeostasis in drug-tolerant persister head and neck cancer cells via lipid-metabolism-driven ferroptosis
Figure 1. Ferroptotic biomarker FSP1 is aberrantly expressed in human HNSCC tissues. (A) Volcano Plot analysis from the Gene Expression Omnibus (GEO) database (GSE72384). (B) Heat map of expression of FSP1 and related genes in TSGH HNSCC cohort (n = 50). (C) IHC staining of FSP1 expression in cisplatin-treatment HNSCC recurrence tissues (left) and nonrecurrence tissues (right) and Q score of FSP1 expression in patients with HNSCC. (D) Graphical representation of FSP1 expression in patients with HNSCC (top image: FSP1 expression in patient tissue; bottom image: FSP1 mRNA expression in patient tissue). (E) Kaplan–Meier curves indicating the effects of low and high BTK expression on the overall survival of patients with HNSCC (n = 259). (F) Ferroptotic biomarkers of FSP1 were aberrantly expressed in box and stage plot of the TCGA HNSCC cohort. (G) Analysis of correlations of FSP1 with iron metabolism, fatty acid metabolism, Iron-responsive element and antioxidant related genes. *p < 0.05, **p < 0.01.