Research Paper Volume 15, Issue 24 pp 14553—14573
Systemic changes induced by autologous stem cell ovarian transplant in plasma proteome of women with impaired ovarian reserves
Figure 1. Plasma proteomic changes following autologous stem cell ovarian transplantation in patients with poor ovarian response. (A) Discriminant analysis plot considering the expression of the 296 quantified proteins, showing a clear separation between the PRE, APHERESIS, and POST samples. (B) Heatmaps depicting the hierarchical clustering of the 11 differentially expressed proteins (DEPs) between PRE and APHERESIS samples and (C) 70 DEPs between PRE and POST samples. The most prominent changes after ASCOT, considering the estimated fold change, highlighted in orange. Dot plot showing the top 30 significantly enriched (FDR < 0.05) GO biological processes three months after autologous stem cell ovarian transplantation (D). The heatmaps are color coded according to protein expression determined by SWATH™ analysis, where yellow and turquoise indicate an increase or decrease in expression, respectively.