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Research Paper Volume 15, Issue 23 pp 13628—13645

Sirtuin 6 activation rescues the age-related decline in DNA damage repair in primary human chondrocytes

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Figure 5. Effect of SIRT6 modulation on chondrocyte repair efficiency. (A) Plots show all individual cells of a representative donor treated with DMSO, MDL-800, or EX-527. (B) The percentage of cells with high levels of DNA damage (>60% of DNA in comet tails). (C) The percentage of cells with low levels of DNA damage (<15% of DNA in comet tails) following DMSO, MDL-800, or EX-527 treatment. Significant differences between groups at each time point (Tukey’s multiple comparisons test, p < 0.05) are denoted by symbols: (*) = DMSO vs. MDL, (#) = MDL vs. EX, (&) = DMSO vs. EX).