Research Paper Volume 16, Issue 1 pp 367—388
Multidimensional comprehensive and integrated analysis of the potential function of TMEM25 in renal clear cell carcinoma with low expression status
Figure 1. Differential expression of RNA levels and protein levels of TMEM25 in ccRCC. (A) Pan-cancer analysis showed that differential expression of TMEM25 RNA levels was present in a variety of cancers, including renal clear cell carcinoma, which showed a significant low expression status. (B) TCGA-KIRC, GSE46699 and GSE40435 cohort differential analysis consistently showed that TMEM25 expression was significantly lower in ccRCC than in normal tissues. (C) Compared with normal renal tubular epithelial cells (HK-2) and the human embryonic kidney cell line(293-T), TMEM25 was also lowly expressed in renal cancer cell lines. (D) The results of the samples from our study center also further confirmed that TMEM25 was expressed much less in ccRCC. (E) The HPA database demonstrated that TMEM25 expression in ccRCC tissues is significantly lower than that in normal tissues. (*p < 0.05, **p < 0.01, ***p < 0.001).