Research Paper Volume 16, Issue 1 pp 191—206

Figure 7. Mn²⁺ and IL-12 combination treatment promoted sustained tumor resistance in vivo. (A) Representative images of memory T cells co-localized by CD3 (red) and CD44 (green) in the tumor center. (B) Representative images of IL-12R expression in the tumor center. (C) Representative images of CD44 immunohistochemical staining of mouse spleens (scale bar, 50 μm). (D) Immunohistochemical quantification. (E) Tumor growth curves in tumor-bearing mice are displayed. Abbreviation: NS: not significant. ^*P < 0.05, ^**P < 0.01, ^***P < 0.001.