Research Paper Volume 15, Issue 24 pp 15382—15401

Figure 8. Assessment of circANKRD42 and cytoskeleton in the healthy population and the key molecular players in aging and pulmonary fibrosis. (A) qRT-PCR result showed that circANKRD42 expression increased with age in a healthy-population group. (B) Phalloidin staining depicted that the cytoskeleton became disorder and underwent disorganized expansion in aging humans compared with young ones. (C) Fluorescence images showed that F-actin increased in 60-year-old healthy people compared with that in 11-year-old ones. (D) Key molecular players were involved in aging and pulmonary fibrosis, including epigenetic alteration (lncIAPF and circANKRD42), mitochondrial dysfunction, abnormal ferroptosis, autophagy, and mechanical forces.