Research Paper Volume 16, Issue 2 pp 985—1001
Prognostic significance of senescence-related tumor microenvironment genes in head and neck squamous cell carcinoma
Figure 2. Distinct characteristics of the senescence related TME subtypes. (A) Heatmap showing the expression of 91 PSTSs of the two subtypes. Red represents high expression and blue represents low expression. Subtype, subsite, stage, T, N and HPV status were used as sample annotations. (B) differentially enriched pathway (subtype 2 vs subtype 1). (C) Forest plot showing somatic mutation in the two subtypes. (D) Barplot showing somatic mutation in the two subtypes. (E) Top 10 most significantly differentially methylated CpGs under comparing subtype 1 and 2. (F) Differences in SASP and GO_senescence ssGSEA score between the two subtypes in the TCGA–HNSC cohort.