Research Paper Volume 15, Issue 24 pp 14930—14944

Figure 5. MiR-206 rescues the effects of HMGA2 on PTC cells. (A) The expression level of miR-206 in HMGA2-WT is lower than that in HMGA2-MUT. The NC group was treated with PBS and the mimic control group was treated with nonsense sequence as the control group of mimics. (B) HMGA2 over-expressed in PTC tissue. (C) HMGA2 over-expressed in PTC cells. (D, E) Western blotting was used to detect the protein expression level of HMGA2 in clinical tissues and cells. (F) HMGA2 negatively correlated with miR-206. (G) HMGA2 promotes PTC cell proliferation and the promotion effect weakened after the addition of shHAGLROS or miR-206. (H) HMGA2 inhibited PTC cell apoptosis and effect weakened after shHAGLROS or miR-206 was added. (I) HMGA2 enhanced cell invasion ability and the enhancement effect faded after adding shHAGLROS or miR-206.