Research Paper Volume 15, Issue 23 pp 14411—14421
MicroRNA 211-5p inhibits cancer cell proliferation and migration in pancreatic cancer by targeting BMP2
Figure 4. Targeting of BMP2 by miR-211-5p in PC. (A) BMP2 was predicted as a potential targets of miR-211-5p. (B) The luciferase activity of BMP2 WT or MUT’3 level of BMP2 affected with miR-211-5p mimics in AsPC-1 and BxPC-3. (C, D) the expression mRNA and protein of BMP2 with miR-211-5p mimics in AsPC-1 and BxPC-3 cells tested by qRT-PCR and western blot. (E) The expression of BMP2 mRNA is upregulated in PC tissues. (F) The relationship of BMP2 and miR-211-5p in PC. (r = −0.3112, p = 0.0174). (G) The overall survival time of PC patients with different expression of BMP2.