ANGPTL4, a direct target of hsa-miR-133a-3p, accelerates lung adenocarcinoma lipid metabolism, proliferation and invasion

Qihao Hu; Shi Chen; Yukun Li; Teng Hu; Jianpeng Hu; Cheng Wang; Fei Yang; Xiang Yang; Feng Zhou; Zhengdong Liu; Wei Xu; Ji Zhang

doi:doi:10.18632/aging.205313

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Research Paper Volume 16, Issue 9 pp 8348—8360

ANGPTL4, a direct target of hsa-miR-133a-3p, accelerates lung adenocarcinoma lipid metabolism, proliferation and invasion

Figure 5. The role of miR-133a-3p/ANGPTL4 axis in LUAD cell proliferation and invasion. (A) The ANGPTL4 protein expression was confirmed by Western blot. (B) The effect of miR-133a-3p/ANGPTL4 axis on LUAD cell proliferation by MTT. (C) The effect of ANGPTL4 KD on lipids metabolism by oil red O. (D) LUAD proliferation ability for miR-133a-3p/ANGPTL4 axis was showed by EdU analysis. The effect of miR-133a-3p/ANGPTL4 axis on LUAD cell migration by wound healing (E) and invasion by Transwell analysis (F).