ANGPTL4, a direct target of hsa-miR-133a-3p, accelerates lung adenocarcinoma lipid metabolism, proliferation and invasion

Qihao Hu; Shi Chen; Yukun Li; Teng Hu; Jianpeng Hu; Cheng Wang; Fei Yang; Xiang Yang; Feng Zhou; Zhengdong Liu; Wei Xu; Ji Zhang

doi:doi:10.18632/aging.205313

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Research Paper Volume 16, Issue 9 pp 8348—8360

ANGPTL4, a direct target of hsa-miR-133a-3p, accelerates lung adenocarcinoma lipid metabolism, proliferation and invasion

Figure 4. ANGPTL4 is a direct target of miR-133a-3p. (A) The expression of miR-133a-3p in LUAD patients based on TCGA database. (B) The overall survival between high or low level of miR-133a-3p LUAD patients. (C) The correlation analysis between ANGPTL4 and miR-133a-3p in LUAD patients. (D) Luciferase reporter analysis for WT or MUT 3′-UTR of ANGPTL4 in A549 cell. The qRT-PCR analysis for the effect of miR-133a-3p on ANGPTL4 expression in A549 cell (E) and H1975 cell (F). ^*P < 0.05 indicates statistical significance compared with the control. ^*P < 0.05 and ^***P < 0.001 indicates statistical significance compared with the control.