Research Paper Volume 15, Issue 23 pp 14372—14383
Melatonin exhibits partial protective effects against gemcitabine- and cisplatin-induced kidney and reproductive injuries in mice
Figure 2. Effects of melatonin and gemcitabine plus cisplatin on the epididymis. The histogram presents the percentage of (A) FSH detection in serum, (B) LH detection in serum, (C) testosterone detection in serum, (D) sperm concentration in the epididymis, and (E) epididymis weight relative to body weight under different treatments. Additionally, (F) a cross-section of the mouse epididymis stained with H&E is shown. GC refers to gemcitabine plus cisplatin, ML represents low dose (10 mg/kg), and MH indicates high-dose (30 mg/kg) melatonin. The data are presented as mean ± SEM, with 6 mice per group (N = 6 mice per group). Statistical significance is denoted as * p < 0.05, ** p < 0.01, and *** p < 0.001 compared to the control or GC group.