Research Paper Volume 15, Issue 23 pp 14372—14383
Melatonin exhibits partial protective effects against gemcitabine- and cisplatin-induced kidney and reproductive injuries in mice
Figure 1. Effects of melatonin and gemcitabine plus cisplatin on the testis. The experimental design is illustrated in the timeline (A). Representative images of the testes sizes in mice are shown in (B). Testis weight relative to body weight under different treatments is presented as a percentage in (C, D) shows a cross-section of a mouse testicle stained with H&E, where L denotes the lumen, EA represents elongated spermatids, GC refers to Gemcitabine plus Cisplatin, ML represents low-dose melatonin (10 mg/kg), and MH represents high-dose melatonin (30 mg/kg). The data are presented as mean ± SEM, with 6 mice per group. Statistical significance is denoted as *** p < 0.001 compared to the control group.