Research Paper Volume 15, Issue 23 pp 14333—14371
Single-cell dissection reveals the role of aggrephagy patterns in tumor microenvironment components aiding predicting prognosis and immunotherapy on lung adenocarcinoma
Figure 4. CD8+T cells differed in metabolism and polarization during aggrephagy. (A) Pseudotime trajectory analysis of aggrephagy genes in CD8+T cells. (B) NMF clustering and annotation in CD8+T cells classified by aggrephagy gene expression features. (C, D) The developing status of NMF-based CD8+T cells subtypes. (E) The number and weight of cell-cell interactions between aggrephagy-related CD8+T cells subtypes and other cell types. (F) A heat map summarizing the outgoing (secreting) and incoming (target) signal pathways of NMF-based aggrephagy-related CD8+T cells subtypes and other cell types. (G) Heatmap showing the comparison of CD8+T cell function signatures (exhaustion score and T cytotoxic score) between aggrephagy-related CD8+T cells subtypes. (H) Heatmap showing significantly different features among aggrephagy-related CD8+T cells subtypes, including Co-stimulations (left), Co-inhibitors (middle), and TFs (right).