Research Paper Volume 15, Issue 23 pp 14333—14371

Figure 10. Multi-omics alteration characteristics of the ADPS in the TCGA dataset. (A, B) GISTIC 2.0-based chromosome amplifications and deletions in high (A) and low (B) ADPS groups. (C) Genomic alteration landscape according to ADPS. Tumor mutation burden (TMB), relative contribution of four mutational signatures, top 20 mutated genes and broad-level CNA (>20%). The proportion of the high and low ADPS groups in each alteration is presented in the right bar charts. (D, E) The mutation frequencies of nine common oncogenic pathways in the high ADPS (D) and low (E) groups. (F) Correlation heatmap of ADPS-related genes with Aneuploidy Score, Homologous Recombination Defects, Fraction Altered, Number of Segments, and Nonsilent Mutation Rate. (G) Difference of TMB score between high and low ADPS group. (H) CNV mutations (gain, loss, none) of ADPS-related genes. ^*p < 0.05; ^**p < 0.01; ^***p < 0.001. Abbreviation: ns: not significant.