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Research Paper Volume 15, Issue 23 pp 14323—14332

Specific knockout of notch-1 attenuates non-alcoholic fatty liver disease by promoting SHP2 phosphorylation

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Figure 6. In vitro experiments verified that Notch-1MAC-KO regulated the expression of oxidative stress-related factors and associated proteins in macrophages of HFD-induced NAFLD mice. (A) Protein band plots of NOX2, NOX4, NLRP3, p-PI3K, p-SHP2 and SREBP2; (B) Relative protein expression levels of NOX2, NOX4, p-PI3K, NLRP3, p-SHP2 and SREBP2; (C) Protein band plots of NOX2, NLEP3, p-PI3K, p-SHP2 and SREBP2; (D) Relative protein expression levels of NOX2, NLEP3, p-PI3K, p-SHP2 and SREBP2. (**p < 0.01, *p < 0.05, ns: p > 0.05; N = 3).