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Research Paper Volume 15, Issue 23 pp 14323—14332

Specific knockout of notch-1 attenuates non-alcoholic fatty liver disease by promoting SHP2 phosphorylation

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Figure 4. Notch-1MAC-KO reduces inflammation-related factors in exosomes of macrophages from mice with HFD-induced NAFLD. (A) Protein band plots of ALIX, CD-9, IL-1β and SREBP1C in exosomes. (B) Relative protein expression levels of ALIX, CD-9, IL-1β and SREBP1C were detected in exosomes isolated from macrophages. (**p < 0.01, *p < 0.05, ns: p > 0.05; N = 6).