Research Paper Volume 15, Issue 23 pp 14306—14322

Figure 7. DOK7 overexpression suppresses the tumor formation of BLCA cells in vivo. (A) Tumor growth was measured every week after the inoculation of T24 cells carrying empty vector or DOK7 expression vector (n = 6 mice in each group); (B) The summary of tumor weight in different groups (vector and DOK7) after mouse sacrifice on day 35; (C) IHC staining of DOK7 and Ki-67 protein expression levels in different groups of tumor samples (vector and DOK7). Both DOK7 and Ki67 were stained as the dark signal in the nuclei, scale bar: 200 μm; (D) WB detection of the phosphorylation levels of JAK1-3 in different groups of tumor samples (vector and DOK7). ^*P < 0.05; ^**P < 0.01; ^***P < 0.001.