Integrated bioinformatics and experiment revealed that cuproptosis is the potential common pathogenesis of three kinds of primary cardiomyopathy

Mengxi Wang; Xiaozhuo Xu; Jianghong Li; Ziwei Gao; Yuhan Ding; Xiaohu Chen; Qian Xiang; Le Shen

doi:doi:10.18632/aging.205298

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Research Paper Volume 15, Issue 23 pp 14210—14241

Integrated bioinformatics and experiment revealed that cuproptosis is the potential common pathogenesis of three kinds of primary cardiomyopathy

Figure 13. Effects of CuCl₂ on morphology, viability and cuproptosis degree of AC16 cells. (A) The effects of CuCl₂ on AC16 cells morphology. (B) The effects of CuCl₂ on AC16 cells viability. (C) The protein expression levels of POLD1, HSP70 and LIAS in AC16 cells (n = 3). (D) The effects of GSH on AC16 cells morphology. (E) The effects of GSH on AC16 cells viability. (F–H) The mRNA expression levels of three K-CRGs in AC16 cells. (^*P < 0.05, ^**P < 0.01).