Research Paper Volume 15, Issue 23 pp 13593—13607
Uncovering a unique pathogenic mechanism of SARS-CoV-2 omicron variant: selective induction of cellular senescence
Figure 1. (A) Immunofluorescence staining of lungs from deceased COVID-19 patients. Lung tissue was stained with p21 (green), actin (red), and nuclei (blue) staining. Scalebar indicates 50 μm. (B) Gene expression of senescence marker CDKN1A and CDKN2A in three distinct lung biopsies of three deceased patients per SARS-CoV-2 variant. Expression levels are displayed normalized to healthy lung tissue from healthy lung transplantation tissue. P calculated by ANOVA with Kruskal-Wallis multiple comparisons tests (B), **p < 0.05.