Research Paper Volume 15, Issue 23 pp 14086—14108
Transcriptome research of human amniocytes identifies hub genes associated with developmental dysplasia in down syndrome
Figure 2. Differentially expressed genes (DEGs) screening and enrichment analysis. (A) Volcano plot of all expressed genes in Normal versus Trisomy. DEGs were filtered through the Fold change ≥1.5 and Q value ≤ 0.05. Dots represent individual genes, with upregulated genes in red, downregulated genes in green and others in gray. (B) List of the top 10 up- and downregulated genes in the DEG gene set. (C) GO enrichment of biological processes (BP) analysis of annotated DEGs; the top 20 are listed. (D) KEGG pathway enrichment analysis of annotated DEGs.