Rewiring of IGF1 secretion and enhanced IGF1R signaling induced by co-chaperone carboxyl-terminus of Hsp70 interacting protein in adipose-derived stem cells provide augmented cardioprotection in aging-hypertensive rats

Parthasarathi Barik; Wei-Wen Kuo; Chia-Hua Kuo; Dennis Jine-Yuan Hsieh; Cecilia Hsuan Day; Jayasimharayalu Daddam; Michael Yu-Chih Chen; V. Vijaya Padma; Marthandam Asokan Shibu; Chih-Yang Huang

doi:doi:10.18632/aging.205287

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Research Paper Volume 15, Issue 23 pp 14019—14038

Rewiring of IGF1 secretion and enhanced IGF1R signaling induced by co-chaperone carboxyl-terminus of Hsp70 interacting protein in adipose-derived stem cells provide augmented cardioprotection in aging-hypertensive rats

Figure 6. Transplantation of CHIP-overexpressing ADSCs (rADSC^CHIP-WT) regulates cardiac function in the aging-SHR model. (A) The schematic diagram illustrates the method for ADSC isolation and their transplantation into aging-SHR. (B, C) EF (%) and %FS were measured through echocardiographic analysis on WKYs, SHRs, and stem cell treated SHRs (N = 3). (D) Heart rate was measured by tail-cuff method of different experimental groups (N = 7). (E) Morphological assessments of rat hearts from different experimental groups, (N = 3). (F) The LVIDd and LVIDs obtained by echocardiographic analysis of different experimental groups, respectively. (^*p < 0.05; ^**p < 0.01; ^***p < 0.001 indicate significant differences).