Research Paper Volume 15, Issue 24 pp 14749—14763
Downregulating miR-184 relieves calcium oxalate crystal-mediated renal cell damage via activating the Rap1 signaling pathway
Figure 8. The alteration of IGF1-PI3K-Akt pathway by miR-184. CaOx (100 μg/mL) was used to treat HK2 cells transfected with miR-184 mimics or miR-184-in. (A, B) Western blot was performed to determine p-IGF1R, IGF1R, p-PI3K, PI3K, Akt, and p-Akt in HK2 cells. *P<0.05, **P<0.01, ***P<0.001 (vs. CaOx+miR-in). NSP>0.05, ^P<0.05, ^^P<0.01, ^^^P<0.001 (vs. CaOx+miR-184 group or CaOx+miR-184-in). N=3.