Research Paper Volume 15, Issue 22 pp 13504—13541
Crosstalk between copper homeostasis and cuproptosis reveals a lncRNA signature to prognosis prediction, immunotherapy personalization, and agent selection for patients with lung adenocarcinoma
Figure 10. The qRT-PCR validation of expression pattern of CoCuLncSig lncRNAs in human tissues and the prognostic potential assessments of CoCuLncSig by pan-cancer analysis. (A) Boxplots showing the expression of CoCuLncSig lncRNAs measured by qRT-PCR in LUAD and adjacent tissues. (B) CoCuLncSig score distribution in pan-cancer and its impact on overall survival, disease specific survival, and progression free survival of each cancer type. (C) Heatmap depicts the variance in expression of CoCuLncSig lncRNAs between normal and tumor tissues across pan-cancer. The histogram at the top illustrates the count of genes exhibiting significant differential expression. Genes that are markedly upregulated and downregulated are identified with red and green markers, respectively. (D) Heatmap shows the prognostic ability of CoCuLncSig lncRNAs in pan-cancer. CoCuLncSig: copper homeostasis and cuproptosis regulated lncRNA signature.