Research Paper Volume 15, Issue 23 pp 13961—13979
Cathepsin V drives lung cancer progression by shaping the immunosuppressive environment and adhesion molecules cleavage
Figure 9. Blockade CTSV suppresses tumor metastases in lung cancer. (A–C) Lung metastasis nodules after tail vein injection of A549 cells (n = 3 mice per group). (D) Kaplan-Meier analysis of the indicated mice. (E) Intravenous injection of A549 cells for metastasis analysis. Representative images of antibody-treated mice and bioluminescent imaging (BLI) are shown (n = 3 mice per group). The representative data are repeated for three independent biological experiments. Student’s t-tests were used for data analysis; ****P-value < 0.0001.