Figure 5. Regulatory relationships among CDKN1A, CDKN2A, TP53 and GADD45B. (A) The correlation between CDKN1A, CDKN2A, TP53, and GADD45B in primary and metastatic patients, respectively. (B–E) The expression or interference vector was used to alter the expression of CDKN1A, CDKN2A, TP53 and GADD45B in A375 respectively, and the expression of other genes was detected from the mRNA and protein levels. * p-value < 0.05, ** p-value < 0.01, *** p-value < 0.001.