Figure 9.The activation of NRF2 reduced the effects of si-HACE1 in model of heart failure. NRF2 and GPX4 protein expression (A, B), MDA/ROS/SOD/GSH/GSH-PX levels (C–G), cell viability (H), LDH activity (I), IL-1α level (J), Iron concentration levels (K), JC-1 disaggregation (L). NRF2 and GPX4 protein expression in blot and immunofluorescence (M, N). ##p<0.01 compared with si-nc group, **p<0.01 compared with si-HACE1 group.
