Aging
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Figure 4
Figure 4.HACE1 inhibited ferroptosis and mitochondrial damage in vitro model. Cell viability (A), LDH activity (B), IL-1α level (C), JC-1 disaggregation (D), calcien-AM/CoCl2 rate level (E), PI positive cells (F), Iron concentration levels (G), GPX4 mRNA expression (H, I) and GPX4 protein expression (J, K) western blot images for GPX4 protein expression (L, M). ##p<0.01 compared with control group or si-nc group.
Figure 4 — HACE1 expression in heart failure patients might promote mitochondrial oxidative stress and ferroptosis by targeting NRF2 | Aging