Research Paper Volume 15, Issue 23 pp 13865—13875

S14G-humanin alleviates acute lung injury by inhibiting the activation of NF-κB

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Figure 6. S14G humanin (HNG) suppressed the activation of NLRP3 signaling in lung tissues of ALI mice. (A) The protein level of genes related with activation of NLRP3 was determined by western blots. (B) Analysis of protein level of NLRP3 level. (C) Analysis of protein level of caspase-1 level. (D) Analysis of protein level of GSDMD N/GSDMD FL level (n=6, **, P<0.05 vs. Control; &, P<0.05, 0.01 vs. LPS group).