Research Paper Volume 15, Issue 23 pp 13854—13864
Long noncoding RNA MEG8 induces an imbalance of Th17/Treg cells through the miR-107/STAT3 axis in Henoch-Schonlein purpura rats
Figure 4. Examination of luciferase activity in NR8383 cells among MEG8, miR-107, and STAT3 expression. (A) MEG8 WT and MEG8 Mut in the bonding locations for MEG8/miR-107. (B) STAT3 WT and STAT3 Mut of bonding locations for STAT3/miR-107. (C) miR-107 WT and miR-107 Mut in bonding locations for MEG8/miR-107, (D) STAT3 and miR-107. (E) MEG8, miR-107, and STAT3 expression. (F) Analysis of the STAT3 protein levels within control CD4+ T cells transfected with the MEG8 overexpression vector, empty vector, si-MEG8 or scramble siRNA. *P <0.01 vs. mimic NC group; #P <0.01 vs. Vector group; ※P <0.01 vs. Scramble group.