Research Paper Volume 15, Issue 23 pp 13753—13775
PBRM1 mutation and WDR72 expression as potential combinatorial biomarker for predicting the response to Nivolumab in patients with ccRCC: a tumor marker prognostic study
Figure 3. Functional analyses of WDR72 in ccRCC. (A) The GO & KEGG analysis and (B) molecular network of 296 positively correlated genes with WDR72 (Spearman corr. >0.6, P< 0.05) in ccRCC. (C) GSEA analysis on High WDR72 vs. Low WDR72 ccRCC tumor tissues in TCGA database. GSEA enrichment plot showing for WP_FATTY_ACID_BETA_OXIDATION and REACTOME_MITOCHONDRIAL_ FATTY_BETA_OXIDATION gene set. (D) Correlation analyses between WDR72 and overlapping genes in Fatty acid degradation and Fatty acid beta oxidation pathway in ccRCC. Abbreviations: GO, Gene Ontology; BP, biological process; KEGG, The Kyoto Encyclopedia of Genes and Genomes; corr., correlation; GSEA, Gene Set Enrichment Analysis; ccRCC, clear cell renal cell carcinoma; NES, normalized enrichment score.