Research Paper Volume 15, Issue 23 pp 13738—13752
Involvement of RFC3 in tamoxifen resistance in ER-positive breast cancer through the cell cycle
Figure 9. Cell cycle of RFC3-overexpressing MCF-7 cells and MCF-7R cells with RFC3 knockdown. (A, B) Flow cytometry experiments showed that the proportion of MCF-7 cells with RFC3 overexpression decreased in S-phase and increased in G1-phase, and cell cycle inhibition was reduced in TAM-treated MCF-7R cells compared with the control group. (C, D) Flow cytometry experiments showed that the proportion of MCF-7R cells with knockdown of RFC3 decreased in S-phase, decreased in G2-phase, and enhanced cell cycle inhibition after TAM treatment compared with the control group.