Research Paper Volume 15, Issue 23 pp 13738—13752
Involvement of RFC3 in tamoxifen resistance in ER-positive breast cancer through the cell cycle
Figure 3. Effects of different concentrations of tamoxifen on the MCF-7 cell cycle and γ-H2AX. (A, B) The cell cycle of MCF-7 cells at a tamoxifen concentration of 10 μM was significantly increased by flow cytometric cell cycle assay compared to the proportion of S-phase of MCF-7 cells at a tamoxifen concentration of 0 μM. (C, D) IF detected that the γ-H2AX protein expression level of MCF-7 cells treated with 10 μM tamoxifen was significantly higher than that of MCF-7 cells treated with 0 μM tamoxifen.