Research Paper Volume 15, Issue 23 pp 13738—13752
Involvement of RFC3 in tamoxifen resistance in ER-positive breast cancer through the cell cycle
Figure 1. Establishment and identification of tamoxifen-resistant cells and MCF-7-like organs. (A) The morphology of the MCF-7R-resistant cell line is rounded and nearly spherical, whereas the MCF-7 parental cells are nearly spindle-shaped. (B) Proliferation rates of MCF-7 and MCF-7R cells after treatment with different concentration gradients of tamoxifen for 48 hours. (C) Growth of MCF-7-like organs in different concentrations of tamoxifen: intact growth at 0 μM, lysis and death at 10 μM. (D) ATP energy.