Research Paper Volume 15, Issue 22 pp 13411—13421
Regulatory mechanisms of miR-212-3p on the secretion of inflammatory factors in monocyte-macrophages and the directed differentiation into osteoclasts in ankylosing spondylitis
Figure 3. The GSEA pathway map was graphed. The results of GSEA manifested that the ERK pathway and other pathways were the enrichment pathways (A). The content of genes in different groups was subjected to statistical analysis. miR-212 was lowly expressed in the disease group and highly expressed in the control group (B). MAPK3 was highly expressed in the disease group (C). The results of correlation analysis revealed that MAPK3 was correlated with MMP (D) and TNFSF1 (E). GSEA, Gene Set Enrichment Analysis; ERK, extracellular-signal-regulated kinase; MAPK, mitogen-activated protein kinase; MMP, matrix metalloproteinase; TNFSF1, tumor necrosis factor ligand superfamily member 1.