Research Paper Volume 15, Issue 22 pp 13345—13367

Figure 2. Consensus clustering identified three novel subtypes based on Fges activity scores. (A) Heatmap shows the consensus clustering matrix of the TARGET-NB cohort based on the activity score of Fges. (B) KM curve shows that the three Fges-derived subtypes exhibit significant differences in prognosis. P-value was obtained by log-rank test. (C) Box plot shows the distribution of activity scores of Fges in three Fges-derived subtypes. P-value was obtained by Wilcoxon rank-sum test. ^****p < 0.0001. (D) Sankey plot shows the associations between the Fges-derived subtypes and clinical features, including gender, COG risk groups, survival status, and INSS stages. (E) Forest plot shows the independent effect of Fges-derived subtypes, along with other clinical features as well as classical groupings, on the prognosis of patients with neuroblastoma. This was determined through multivariate Cox regression analysis.