Research Paper Volume 15, Issue 22 pp 12702—12722
Chronological aging impacts abundance, function and microRNA content of extracellular vesicles produced by human epidermal keratinocytes
Figure 4. A specific microRNA signature can distinguish EVs from young, aged and senescent keratinocytes. (A) Hierarchical clustering of the EVs samples based on their microRNA signature Keratinocytes supernatants from young or aged skin were used to purify EVs, cultured at early (p2) or late passage (p6). (B) Principal component analysis of the EVs samples based on their microRNA signature, on the left PC1 (19% of the variance) vs. PC2 (15% of the variance), on the right PC2 vs. PC3 (11% of the variance).