Research Paper Volume 15, Issue 22 pp 12738—12748
Contribution of membrane raft redox signalling to visfatin-induced inflammasome activation and podocyte injury
Figure 2. NADPH oxidase inhibition attenuates inflammasome formation induced by visfatin in podocytes. (A) Confocal images representing the colocalization of NLRP3 (green) with ASC (red) and NLRP3 (green) with caspase-1 (red) in podocytes (original magnification, 400x). (B) Summarized data showing the fold change of Pearson correlation coefficient (PCC) for the colocalization of NLRP3 with ASC and NLRP3 with caspase-1 (n = 6). Values are means ± SEM, showing fold changes as compared with control. Abbreviations: Ctrl: Control; Veh: Vehicle; Vis: Visfatin; DPI: diphenyleneiodonium; MCD: methyl-β-cyclodextrin. *P < 0.05 vs. control; #P < 0.05 vs. visfatin.