Research Paper Volume 15, Issue 22 pp 13287—13311

Figure 3. Expression pattern of SRSFs and their association with genome instability in human cancer. (A) Heatmap demonstrating differential expression of SRSFs between tumor and normal tissue. (B) Unsupervised consensus clustering based on SRSFs mRNA expression identifies two distinct patient clusters. (C) Sample distribution across 33 cancer types in the two patient clusters. The values represent the proportion of the two clusters in the different cancer types. (D–H) Differences in five scores (D, mutation burden; E, SCNA burden; F, aneuploidy scores; G, LOH; H, HRD) representing genome instability between the two clusters. The differences between the two clusters were tested by Wilcox’s rank sum test. The asterisks represented the statistical P-value (*P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001).