Research Paper Volume 15, Issue 22 pp 13239—13264

Figure 6. QFY ameliorates the inflammatory response and improves learning and memory ability in AD rats. (A) Escape latency during the visible platform phase of the Morris water maze test. (B) The number of crossings over the previously hidden platform area in the Morris water maze test. (C) Escape latency during the acquisition phase of the Morris water maze test. (D) The trajectories of the rats looking for hidden platforms on Day 5. N = 6 animals/group. The data are expressed as the means ± SDs. ^*p < 0.05, ^**p < 0.01, compared with the control; ^#P < 0.05, ^##P < 0.01, compared with the M group; different color symbols represent different groups compared to the model group. (E) Detection of TLR4 and AGER protein expression by Western blot. (F) The mRNA expression levels of IL-1β in different groups. (G) The mRNA expression levels of TNF-α in different groups. (H) The mRNA expression levels of TLR4 in different groups. (I) The mRNA expression levels of NF-κB in different groups. (J) Statistical results of the relative expression levels of TLR4 protein. (K) Statistical results of the relative expression levels of AGER protein. N = 3 animals/group. The data are expressed as the means ± SDs. ^*p < 0.05, ^**p < 0.01, compared with the control; ^#P < 0.05, ^##P < 0.01, compared with the M group.