Research Paper Volume 15, Issue 22 pp 13239—13264
Qi Fu Yin ameliorates neuroinflammation through inhibiting RAGE and TLR4/NF-κB pathway in AD model rats
Figure 4. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis and molecular docking of major components to targets. (A) Top 20 biological processes (BP) of GO terms sorted by P values < 0.01. Counts of genes and P values related to each BP term are shown. The y-axis represents BP terms, and the x-axis shows counts of genes annotated to the BP terms. (B) Top 20 enriched pathways. The x-axis shows the number of genes in the given gene set that were annotated to specific pathways, while the y-axis represents the pathways. (C) KEGG second class enrichment analysis of 102 potential targets related to AD. The x-axis shows the numbers of genes enriched in certain pathways, while the y-axis represents pathway terms. (D) Binding energies of the ligands and receptors. The lower the binding energy is, the greater the stability of the ligand and receptor. (E) AGER-stigmasterol and AGER-β-sitosterol. (F) NF-κB-stigmasterol and NF-κB-β-sitosterol. (G) TLR4-stigmasterol and TLR4-β-isorhamnetin.