Research Paper Volume 15, Issue 22 pp 13176—13193
Investigating EGF and PAG1 as necroptosis-related biomarkers for diabetic nephropathy: an in silico and in vitro validation study
Figure 3. Expression profiles of necroptosis-related biomarkers in the scRNA-seq data. A dimension reduction plot (A) and boxplot (B) showing the profiles of EGF expression in different cell types. The expression levels of PAG1 in scRNA-seq data as shown as a dimension reduction plot (C) and boxplot (D). ZFP36 expression profile in different types of cells in the GSE131882 as shown in a dimension reduction plot (E) and boxplot (F). (Wilcoxon’s test; *p<0.05; **p<0.01; ***p<0.001). Abbreviations: LOH, loop of Henle cell; CD-ICA, collecting duct type A intercalated cell; CT, connecting tubule cell; PEC, parietal epithelial cell; CD-ICB, collecting duct type B intercalated cell; PST, proximal straight tubule cell; DCT, distal convoluted tubule cell; PODO, podocyte cell; ENDO, endothelium cell; PCT, proximal convoluted tubule cell; FIB, fibroblast cell; MES, mesangial cell; LEUK, leukocyte cell; DN: diabetic nephropathy; UMAP: uniform manifold approximation and projection.