Research Paper Volume 15, Issue 22 pp 13163—13175

Figure 4. M2 macrophages polarized by hypoxic exosomes promote the migration of chondrosarcoma cells. (A) Schematic illustration of the in vitro indirect co-culture system. (B) The in vitro Transwell co-culture system determined the migratory capacity of chondrosarcoma cells (SW1353) co-cultured with exosome-treated macrophages. Representative photographs of migratory cells on the membrane are shown as morphometric analyses of migratory cells. All replicate number ≧ 3. ^#p < 0.05 compared with the DMEM; ^*p < 0.05 compared with the SW1353-N-exo group.