Research Paper Volume 15, Issue 21 pp 11764—11781

Figure 1. Doxycycline extends lifespan of C. elegans. (A) Survival curves of worms treated with different concentrations of doxycycline: control (FUdR alone) (blue), 13 μM doxycycline (red) and 130 μM doxycycline (green). Statistical analysis was performed using Log-rank (Mantel-Cox), ^****p < 0.0001 (control vs. 13 μM), ^***p < 0.001 (control vs. 130 μM). (B) Median survival and maximal lifespan are represented. Experiments were carried out in triplicate, with 15 worms for each replicate.