1,5-anhydro-D-fructose induces anti-aging effects on aging-associated brain diseases by increasing 5’-adenosine monophosphate-activated protein kinase activity via the peroxisome proliferator-activated receptor-γ co-activator-1α/brain-derived neurotrophic factor pathway

Kiyoshi Kikuchi; Shotaro Otsuka; Seiya Takada; Kazuki Nakanishi; Kentaro Setoyama; Harutoshi Sakakima; Eiichiro Tanaka; Ikuro Maruyama

doi:doi:10.18632/aging.205228

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Research Paper Volume 15, Issue 21 pp 11740—11763

1,5-anhydro-D-fructose induces anti-aging effects on aging-associated brain diseases by increasing 5’-adenosine monophosphate-activated protein kinase activity via the peroxisome proliferator-activated receptor-γ co-activator-1α/brain-derived neurotrophic factor pathway

Figure 8. Overview of experimental protocols. (A) Sprague–Dawley rats were used to show effects of intraperitoneal 1,5-AF on thrombotic stroke. (B) SHRSPs were used to show effects of oral 1,5-AF on hypertension-related spontaneous stroke. (C) SAMP8 mice were used to show effects of oral 1,5-AF on aging-associated brain diseases. Abbreviations: 1,5-AF: 1,5-anhydro-D-fructose; SAMP8: senescence-accelerated mouse-prone 8; SHRSPs: stroke-prone spontaneously hypertensive rats.